Experience-related alterations in white matter structure and gene expression in adult rats
作者： Nicola R. Sibson , Peter De Weerd , Peter De Weerd , Anderson Winkler , Alexandre A. Khrapitchev
DOI: 10.1101/532572
关键词:
摘要: ABSTRACT White matter (WM) plasticity during adulthood is a recently described phenomenon by which experience can shape brain structure. It has been observed in humans using diffusion tensor imaging (DTI). However, it remains unclear mechanisms drive or underlie WM adulthood. Here, we combined DTI and mRNA expression analysis examined the effects of somatosensory adult rats. Somatosensory resulted differences grey C-FOS expression, marker cortical activity, barrel cortex correlated with structural measures, suggesting that activity-dependent. Analysis myelin-related genes revealed higher myelin basic protein WM, while genome-wide RNA sequencing identified 134 differentially-expressed regulating proteins involved functions related to cell proliferation differentiation, neuronal activity modulation regulation myelination. In conclusion, macroscale measures response are supported molecular evidence, strongly suggest myelination as, at least, one underlying mechanisms.
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