A Prospective Study of the Volume of Pleural Fluid Required for Accurate Diagnosis of Malignant Pleural Effusion

摘要: Background This is a prospective study to define the volume of pleural fluid adequate for maximal yield cytologic analysis fluid. Methods Patients undergoing diagnostic thoracentesis with malignancy in differential diagnosis were enrolled study. The first 50 mL put specimen cup, and subsequent was collected drainage bag. Both samples sent evaluation. cytologist blinded as which being evaluated. Results Forty-four patients (21 men, 23 women; mean [± SD] age, 46 ± 11.1 years) average “large-volume” 890 375 (range, 250 1,800). Although malignant involvement had never been documented any patients, 31 received prior thoracentesis. Cytologic tests positive 44 (55%). In group an established history cancer, cells 19 33 (58%). all effusion, both 50-mL large-volume cytologically identical. 21 negative cytology findings, there again 100% concordance between larger samples. minimum has matter debate. strongest data date came from retrospective 2002. Conclusion Our now unequivocally supports concept that submission > does not increase yield.