The benzodiazepine receptor partial agonists, bretazenil (Ro 16-6028) and Ro 17-1812, affect saccharin preference and quinine aversion in the rat.

摘要: A previous experiment had shown that the benzodiazepine receptor (BZR) agonist, clonazepam, selectively increased consumption of a 0.05% sodium saccharin solution without change in water intake, two-choice preference test. The first aim this study was to investigate effects two partial agonists, bretazenil (Ro 16-6028) and Ro 17-1812, same results showed both drugs produced similar those observed earlier with clonazepam. second compounds on 0.005% quinine Both alteration intake. In addition, separate single-choice acceptance tests, significantly familiar, highly palatable 3% sucrose solution. These data are considered relation alternative hypotheses for BZR-mediated choice tests.