Myocardial recovery after cardiac resynchronization therapy in left bundle branch block-associated idiopathic nonischemic cardiomyopathy: A NEOLITH II substudy.

摘要: Background Baseline predictors of myocardial recovery after cardiac resynchronization therapy (CRT) in left bundle branch block (LBBB)-associated idiopathic nonischemic cardiomyopathy (NICM) are unknown. Methods A retrospective study included subjects with NICM, ventricular ejection fraction (LVEF) ≤35%, and LBBB. Myocardial was defined as post-CRT LVEF ≥50%. Logistic regression analyses described associations between baseline characteristics recovery. Cox estimated the hazard ratio (HR) status adverse clinical events. Results In 105 (mean age 61 years, 44% male, mean initial 22.6% ± 6.6%, 81% New York Heart Association class III, 98% CRT-defibrillators), CRT observed 56 (54%) subjects. Hypertension, heart rate, serum blood urea nitrogen (BUN) had negative univariable analyses. These persisted multivariable analysis: hypertension (odds (OR), 0.40; 95% confidence interval (CI), 0.17-0.95; p = 0.04), rate (OR per 10 bpm, 0.69; CI, 0.48-0.997; 0.048), BUN 1 mg/dl, 0.94; 0.88-0.99; 0.04). Subjects ≥50%, when compared to Conclusion LBBB-associated associated absence hypertension, lower BUN. Those fewer