The reliability and validity of outcome measures for atopic dermatitis in patients with pigmented skin: A grey area

摘要: Abstract Background Outcome measures for atopic dermatitis (AD) patients with pigmented skin have neither been developed nor validated. Objective To compare the reliability and validity of four common AD outcome in various levels darkness. Method The inter- intra-rater construct EASI (Eczema Area Severity Index), objective-SCORing Atopic Dermatitis (oSCORAD), Three Items index (TIS) Six Areas, Sites (SASSAD) were evaluated 18 darkness, using their full body photographs, by five trained clinicians. Results inter-rater intraclass coefficient (ICCs) 95% confidence intervals poor highly patients: -.054(-.200 to .657), oSCORAD -.089(-.206 .598), TIS -.21(-.24 .147), SASSAD -.071(-.200 .631); fair mildly .464(.140-.839), .588(.265-.89), TIS.524(.200-.865), .41(.045-.775); good non-pigmented .64(.330-.908), .586(.263-.889), .403(.09-.809), .667(.358-.916). Erythema likely contributed variability. Construct had significant correlations across all patients, but no patients. Conclusion variations erythema perception being a contributor.