In Silico Derived Peptides for Inhibiting the Toxin–Antitoxin Systems of Mycobacterium tuberculosis : Basis for Developing Peptide-Based Therapeutics
作者： Shobana Sundar , Madhu Pearl Rajan , Shanmughavel Piramanayagam
DOI: 10.1007/S10989-018-9792-8
关键词:
摘要: Toxin–antitoxin (TA) systems of Mycobacterium tuberculosis (Mtb) is a prerequisite for the bacterium to survive in extreme conditions. Antimicrobial peptides inhibiting formation these complexes provide novel strategy TB drug discovery process. Absence TA genes human, makes as an attractive target development. In this study using Peptiderive server, we have derived number potential inhibitory nine complexes—VapBC3, VapBC5, VapBC11, VapBC15, VapBC26, VapBC30, RelBE2, RelJK, MazEF4 Mtb. We studied about common interacting toxin residues with antitoxin and peptide. Further, Cluspro compared binding efficacy silico published toxins VapC26, VapC30 MazF. Thus, would serve basis developing peptide based therapeutics
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