Overlapping Molecular Pathways Leading to Autism Spectrum Disorders, Fragile X Syndrome, and Targeted Treatments
作者： Maria Jimena Salcedo-Arellano , Ana Maria Cabal-Herrera , Ruchi Harendra Punatar , Courtney Jessica Clark , Christopher Allen Romney
DOI: 10.1007/S13311-020-00968-6
关键词:
摘要: Autism spectrum disorders (ASD) are subdivided into idiopathic (unknown) etiology and secondary, based on known etiology. There hundreds of causes ASD most them genetic in origin or related to the interplay environmental toxicology. Approximately 30 50% etiologies can be identified when using a combination available testing. Many these gene mutations either core components Wnt signaling pathway their modulators. The full mutation fragile X mental retardation 1 (FMR1) leads syndrome (FXS), common cause monogenic ASD, accounting for ~ 2% cases. is an overlap molecular mechanisms those with FXS, interaction between various pathways suggested during development autistic brain. This review summarizes cross talk neurobiological found FXS. These currently under evaluation target specific treatments search reversal abnormalities both
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Zai-Yun Long, Ya-Min Wu, Sen Li, Yuan Liu, Li Wang, Wnt signaling pathway participates in valproic acid-induced neuronal differentiation of neural stem cells. International Journal of Clinical and Experimental Pathology. ,vol. 8, pp. 578- 585 ,(2015)
James E. Crandall, Timothy Goodman, Deirdre M. McCarthy, Gregg Duester, Pradeep G. Bhide, Ursula C. Dräger, Peter McCaffery, Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex. Journal of Neurochemistry. ,vol. 119, pp. 723- 735 ,(2011) , 10.1111/J.1471-4159.2011.07471.X
Adrian L. Oblak, Terrell T. Gibbs, Gene J. Blatt, Decreased GABAB receptors in the cingulate cortex and fusiform gyrus in Autism Journal of Neurochemistry. ,vol. 114, pp. 1414- 1423 ,(2010) , 10.1111/J.1471-4159.2010.06858.X
Xinglong Wang, Mike Snape, Eric Klann, Jeremy G. Stone, Avneet Singh, Robert B. Petersen, Rudy J. Castellani, Gemma Casadesus, Mark A. Smith, Xiongwei Zhu, Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome Journal of Neurochemistry. ,vol. 121, pp. 672- 679 ,(2012) , 10.1111/J.1471-4159.2012.07722.X
Shinya Yufune, Yasushi Satoh, Isao Takamatsu, Hiroyuki Ohta, Yasushi Kobayashi, Yumiko Takaenoki, Gilles Pagès, Jacques Pouysségur, Shogo Endo, Tomiei Kazama, Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice Scientific Reports. ,vol. 5, pp. 10252- 10252 ,(2015) , 10.1038/SREP10252
C J Yatawara, S L Einfeld, I B Hickie, T A Davenport, A J Guastella, The effect of oxytocin nasal spray on social interaction deficits observed in young children with autism: a randomized clinical crossover trial Molecular Psychiatry. ,vol. 21, pp. 1225- 1231 ,(2016) , 10.1038/MP.2015.162
Jeffrey P. MacKeigan, Darcy A. Krueger, Differentiating the mTOR inhibitors everolimus and sirolimus in the treatment of tuberous sclerosis complex Neuro-oncology. ,vol. 17, pp. 1550- 1559 ,(2015) , 10.1093/NEUONC/NOV152
Paolo Devanna, Sonja C. Vernes, A direct molecular link between the autism candidate gene RORa and the schizophrenia candidate MIR137 Scientific Reports. ,vol. 4, pp. 3994- 3994 ,(2015) , 10.1038/SREP03994
Brigid Adviento, Iris L Corbin, Felicia Widjaja, Guillaume Desachy, Nicole Enrique, Tena Rosser, Susan Risi, Elysa J Marco, Robert L Hendren, Carrie E Bearden, Katherine A Rauen, Lauren A Weiss, Autism traits in the RASopathies Journal of Medical Genetics. ,vol. 51, pp. 10- 20 ,(2014) , 10.1136/JMEDGENET-2013-101951
Craig A. Erickson, Logan K. Wink, Maureen C. Early, Elizabeth Stiegelmeyer, Lauren Mathieu-Frasier, Vanessa Patrick, Christopher J. McDougle, Brief Report: Pilot Single-Blind Placebo Lead-in Study of Acamprosate in Youth with Autistic Disorder. Journal of Autism and Developmental Disorders. ,vol. 44, pp. 981- 987 ,(2014) , 10.1007/S10803-013-1943-3