Vessel co-option in primary human tumors and metastases: an obstacle to effective anti-angiogenic treatment?

摘要: Angiogenesis has been regarded as essential for tumor growth and progression. Studies of many human tumors, however, suggest that their microcirculation may be provided by nonsprouting vessels a variety tumors can grow metastasize without angiogenesis. Vessel co-option, where cells migrate along the preexisting host organ, is an alternative blood supply. co-option occur in malignancies, but so far mostly reported highly vascularized tissues such brain, lung, liver. In primary metastatic lung cancer liver metastasis from different origins, much 10-30% are to use this addition, vessel introduced potential explanation antiangiogenic drug resistance, although impact clinical setting still further explored. review we discuss with specific examples secondary consideration implications