Lobelane analogues as novel ligands for the vesicular monoamine transporter-2
作者： Guangrong Zheng , Linda P. Dwoskin , Agripina G. Deaciuc , Jun Zhu , Marlon D. Jones
DOI: 10.1016/J.BMC.2005.04.013
关键词:
摘要: A series of lobelane analogues has been synthesized and their structure–activity relationships at the vesicular monoamine transporter-2 (VMAT2) have evaluated. The most potent in this were cis-2,6-piperidino analogues, 25b, 27b, 28b, 30b, with Ki values ranging from 430 to 580 nM.
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