Absolute Configuration Determination of Azulenyl Diols Isolated From Asymmetric Pinacol Coupling.
作者： Eugenia Andreea Dragu , Jean-Valere Naubron , Anamaria Hanganu , Alexandru C. Razus , Simona Nica
DOI: 10.1002/CHIR.22523
关键词:
摘要: A convenient enantioselective approach for the pinacol coupling of 1-acetylazulene involving easily accessible (R)- or (S)-BINOLs as chiral additive is reported. This supposes preformation titanium-BINOL complex in 1:2 ratio and subsequent reduction with zinc when, 2,3-di(azulen-1-yl)butane-2,3-diol can be isolated around 60% enantiomeric excess. The absolute configuration enantiomers was assigned by comparison experimental Boltzmann-weighted calculated VCD ECD spectra (+)-(2S;3S)-di(azulen-1-yl)butane-2,3-diol. Chirality 27:826-834, 2015. © 2015 Wiley Periodicals, Inc.
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