Hypoxic Pulmonary Vascular Smooth Muscle Cell Proliferation

摘要: Pulmonary arterial smooth muscle cell (PASMC) proliferation in response to hypoxia is thought be a key component of the vascular remodeling that occurs chronic hypoxic pulmonary hypertension. Many disorders, including obstructive disease, are associated with hypoxia, and when hypertension right heart failure develop due remodeling, patient survival impaired. Hypoxia one factors known cause secondary [1]. According WHO statement 1996, there were approximately 140 million people living at altitudes above 2500m several areas permanent habitation excess 4000 m. After weeks exposure high altitude, lowlanders hypertension, which not completely reversed by supplemental oxygen [2], suggesting development lung [3]. Secondary characterized cells fibroblasts small vessels [4-6]. These results suggest enhancement PASMC contributes progression hypoxia-associated In animals, has been shown wall thickening inducing [7-9]. Most commonly, studied rats or mice exposed 10% for 2 8 [9,10]. animals muscular arteries increase thickness distal extension migration into normally non-muscular can observed (Figure 1).