A systematic review and meta-analysis of the diagnostic accuracy of pyruvate kinase M2 isoenzymatic assay in diagnosing colorectal cancer
作者： Mallikarjuna Uppara , Franklin Adaba , Alan Askari , Susan Clark , George Hanna
DOI: 10.1186/S12957-015-0446-4
关键词:
摘要: Screening programmes exist in many countries for colorectal cancer. In recent years, there has been a drive non-invasive screening marker of higher sensitivity and specificity. Stool-based pyruvate kinase isoenzyme M2 (M2-PK) is one such biomarker under investigation. The aim this systematic review meta-analysis to determine the diagnostic accuracy, specificity M2-PK as tool A literature search Ovid Medline, EMBASE Google Scholar was carried out. strategy restricted human subjects studies published English. Data on were extracted pooled. Statistical analysis conducted using summary receiver operating characteristic (SROC) curve methodology. total eight suitable data synthesis analysis. Our showed pooled be 79% (CI 73%–83%) 80% 73%–86%), respectively. accuracy 0.85(0.82–0.88). Faecal assay relatively good high
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