Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation.
作者： Birgitte Holst , Thue W Schwartz
DOI: 10.1016/J.TIPS.2004.01.010
关键词:
摘要: Abstract Ghrelin plays a key role as the major orexigenic hormone from gastrointestinal tract to hypothalamic areas that govern food intake, balancing against multitude of anorectic hormones, such leptin, insulin and PYY 3–36 . Surprisingly, even in absence agonist, ghrelin receptor signals with ∼50% activity. Thus, although antagonists are expected reduce meal-associated inverse agonists receptor, by blocking constitutive activity, might lower set-point for hunger between meals, eliminating craving second orders, desserts snacks.
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