Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape.
作者： Reiner A Veitia , Sandrine Caburet , None
关键词:
摘要: We show that the predicted signal peptide (SP) sequences of secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions divergent protein segments do encode SPs. Thus, such SPs have undergone extensive sequence turnover with full preservation functionality. This can be explained by a pervasive accumulation neutral compensatory mutations. An exploration potential evolutionary landscape some presented. Some these highlight an apparent paradox: they encoded, definition, orthologous DNA are, given their striking divergence, examples what called functional convergence.
biomedcentral.com
springer.com
biologydirect.com参考文章(26)
S Shimasaki, F Otsuka, R K Moore, G F Erickson, The role of bone morphogenetic proteins in ovarian function. Reproduction in domestic ruminants V. Proceedings of the Sixth International Symposium on Reproduction in Domestic Ruminants held in Crieff, Scotland, UK, August 2002.. ,vol. 61, pp. 323- 337 ,(2003)
Carl-Henrik Heldin, Kohei Miyazono, Peter ten Dijke, TGF-beta signalling from cell membrane to nucleus through SMAD proteins Nature. ,vol. 390, pp. 465- 471 ,(1997) , 10.1038/37284
Lukas Käll, Anders Krogh, Erik L.L Sonnhammer, A combined transmembrane topology and signal peptide prediction method. Journal of Molecular Biology. ,vol. 338, pp. 1027- 1036 ,(2004) , 10.1016/J.JMB.2004.03.016
Ya Ming Hou, Paul Schimmel, Functional compensation of a recognition-defective transfer RNA by a distal base pair substitution. Biochemistry. ,vol. 31, pp. 10310- 10314 ,(1992) , 10.1021/BI00157A019
Motoo Kimura, Some models of neutral evolution, compensatory evolution, and the shifting balance process Theoretical Population Biology. ,vol. 37, pp. 150- 158 ,(1990) , 10.1016/0040-5809(90)90032-Q
O. Hashimoto, R. K. Moore, S. Shimasaki, Posttranslational processing of mouse and human BMP-15: Potential implication in the determination of ovulation quota Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 5426- 5431 ,(2005) , 10.1073/PNAS.0409533102
Sophie Maisnier-Patin, Dan I Andersson, Adaptation to the deleterious effects of antimicrobial drug resistance mutations by compensatory evolution. Research in Microbiology. ,vol. 155, pp. 360- 369 ,(2004) , 10.1016/J.RESMIC.2004.01.019
Besma Lakhal, Paul Laissue, Rim Braham, Hatem Elghezal, Ali Saâd, Marc Fellous, Reiner A Veitia, None, A novel BMP15 variant, potentially affecting the signal peptide, in a familial case of premature ovarian failure. Clinical Endocrinology. ,vol. 71, pp. 752- 753 ,(2009) , 10.1111/J.1365-2265.2009.03571.X
Daniel Perlman, Harlyn O. Halvorson, A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides Journal of Molecular Biology. ,vol. 167, pp. 391- 409 ,(1983) , 10.1016/S0022-2836(83)80341-6
Malcolm Whitman, Nodal Signaling in Early Vertebrate Embryos: Themes and Variations Developmental Cell. ,vol. 1, pp. 605- 617 ,(2001) , 10.1016/S1534-5807(01)00076-4