Genomics in Organ Transplantation

摘要: Since the first organ transplantation conducted in 1953, over -all processes of have been remarkably devel -oped not only surgical techniques but also peri-surgical treat -ment including appropriate matching donor, immunosuppressive agents, etc. [1]. Many types study associated with genomics developed (Table 1). By virtue these successful improvements, there were more than 28,000 cases transplantations in-cluding liver, heart, and kidney KOREA since 2000 (KOrean Network for Organ Sharing, KONOS). And now, is considered as a routine curative treatment end stage diseases kidney, liver. Even though improvements progresses, acute or chronic rejection rate allograft still significant, it up to 60% [2].The completion human genome project initiated new era translational medicine. The Human Genome Project (HGP) was performed determine chemical nucleotide sequences which consist DNA identify genes physically functionally. at 2003, this information has widely used find disease related mark -ers, discover genetic variations, personal diversities [3]. Like beads array technology, next generation sequencing (NGS) brought us insight into molecular biology. Especially sensitivity technology made possible spe-cific markers heterogeneous group patients supply cus -tomized medicine take care different diseases. NGS shifts paradigm from protocol-based personalized can be applied suffering failure failed transplanta -tion, estimating rates using specific biomarkers iden -tified by between patient donors, finding best match -ing donor transplanting patient, achieving success -ful transplantation. In review, we introduce current available genomic technologies summarize potential benefits