Disrupted salience network functional connectivity and white-matter microstructure in persons at risk for psychosis: findings from the LYRIKS study.

摘要: Background Salience network (SN) dysconnectivity has been hypothesized to contribute schizophrenia. Nevertheless, little is known about the functional and structural of SN in subjects at risk for psychosis. We that connectivity would be disrupted with At-Risk Mental State (ARMS) associated symptom severity disease progression. Method examined 87 ARMS 37 healthy participants using both resting-state magnetic resonance imaging diffusion tensor imaging. Group differences were a seed-based approach tract-based spatial statistics. Subject-level measures indices regions correlated CAARMS scores compared between without transition Results exhibited reduced left ventral anterior insula other regions. Reduced fractional anisotropy (FA) axial diffusivity also found along white-matter tracts close proximity connectivity, including frontal-striatal-thalamic circuits cingulum. FA extracted from these individual group. Furthermore, bilateral forceps minor further who transitioned psychosis after 2 years. Conclusions Our findings support insular proximal hypothesis early stages Further developed, combined assays may inform prognosis persons at-risk