Emergence of vertebrate retroviruses and envelope capture.

摘要: Retroviruses are members of the superfamily retroelements, mobile genetic elements that transpose via an RNA intermediate. However, retroviruses distinct from other retroelements in their "transposition" is not confined to single cells but extends neighboring and organisms. As such, these defined as infection. It appears a key step conversion retrotransposon into retrovirus modular acquisition or capture envelope glycoprotein (Env) which facilitates dissemination its initial host cell. Here we present several examples for has been identified. Indeed, may explain notable conservation env sequences among otherwise phylogenetically distant retroviruses. In recent example, sequence homologies reported between murine leukemia viruses (MLV) human T cell (HTLV) argue favor by latter. Env can provide new adaptive properties replication-competent addition altering range. Also, captured alter spectrum physiological affects infection The elucidation such exchanges thereof should contribute significantly clarification retroviral phylogeny, insight pathogenesis, discovery