Central sensitization theory of migraine: Clinical implications

摘要: The clinical science of migraine headache continues to evolve. Theories the pathophysiology have progressed from early vascular basis more complex current theories that emphasize centrality neuronal dysfunction. most recently articulated theory is central sensitization hypothesis, which proposes altered processing sensory input in brainstem, principally trigeminal nucleus caudalis, could account for many temporal and symptomatic features migraine, as well its poor response triptan therapy when such treatment initiated hours after onset pain. Both preclinical data support theory. A critical implication this drugs are capable either aborting or arresting process sensitization, prominently dihydroergotamine, may a unique role migraine. An additional, highly practical, based upon finding cutaneous allodynia-pain arising innocuous stimulation skin, hair brushing application cosmetics-is an easily identifiable marker sensitization. Thus, presence absence allodynia can be integrated into routine assessment utilized determinant treatment. Future basic research on likely ongoing importance field.