Synthesis and Biological Evaluation of Some Quinazoline Heterocyclic Derivatives

作者: R. R. Dangi , N. S. Chundawat , K. L. Ameta

DOI: 10.1007/978-81-322-1850-0_13

关键词:

摘要: Owing to the significant biological activities, quinazoline derivatives have drawn more and attention in synthesis bioactivities research. This chapter summarizes recent advances investigations of activities derivatives. According main method authors adopted their research design, those synthetic methods include microwave-assisted reaction, ultrasound-promoted metal-mediated water phase-transfer catalysis reaction. The synthesized are also discussed.

参考文章(76)
G Jansen, L Brunton, R Kimbell, A L Jackman, J M Wardleworth, M N Smith, G W Aherne, F T Boyle, T C Stephens, Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase. Clinical Cancer Research. ,vol. 3, pp. 911- 921 ,(1997)
V. Alagarsamy, V. Raja Solomon, K. Dhanabal, Synthesis and pharmacological evaluation of some 3-phenyl-2-substituted-3H-quinazolin-4-one as analgesic, anti-inflammatory agents. Bioorganic & Medicinal Chemistry. ,vol. 15, pp. 235- 241 ,(2007) , 10.1016/J.BMC.2006.09.065
Sanjita Sasmal, D. Balasubrahmanyam, Hariprasada R. Kanna Reddy, Gade Balaji, Gujjary Srinivas, Srisailam Cheera, Chandrasekhar Abbineni, Pradip K. Sasmal, Ish Khanna, V.J. Sebastian, Vikram P. Jadhav, Manvendra P. Singh, Rashmi Talwar, J. Suresh, Dhanya Shashikumar, K. Harinder Reddy, V. Sihorkar, Thomas M. Frimurer, Øystein Rist, Lisbeth Elster, Thomas Högberg, Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 2 Bioorganic & Medicinal Chemistry Letters. ,vol. 22, pp. 3163- 3167 ,(2012) , 10.1016/J.BMCL.2012.03.049
Michael S. Malamas, Jane Millen, Quinazolineacetic acids and related analogues as aldose reductase inhibitors. Journal of Medicinal Chemistry. ,vol. 34, pp. 1492- 1503 ,(1991) , 10.1021/JM00108A038
Yu-Ping Liu, De-Cai Yin, Hai-Tao Chen, Bao-Guo Sun, Rapid Synthesis of Flavor Compound 4-Ethyloctanoic Acid under Microwave Irradiation International Journal of Molecular Sciences. ,vol. 11, pp. 4165- 4174 ,(2010) , 10.3390/IJMS11104165
A. A. Aly, Synthesis of Novel Quinazoline Derivatives as Antimicrobial Agents Chinese Journal of Chemistry. ,vol. 21, pp. 339- 346 ,(2010) , 10.1002/CJOC.20030210324
Mario Alvarado, María Barceló, Laura Carro, Christian F. Masaguer, Enrique Raviña, Synthesis and biological evaluation of new quinazoline and cinnoline derivatives as potential atypical antipsychotics. Chemistry & Biodiversity. ,vol. 3, pp. 106- 117 ,(2006) , 10.1002/CBDV.200690001
Stephanie L Matheson, Fouad Brahimi, Bertrand J Jean-Claude, The combi-targeting concept: intracellular fragmentation of the binary epidermal growth factor (EGFR)/DNA targeting “combi-triazene” SMA41 Biochemical Pharmacology. ,vol. 67, pp. 1131- 1138 ,(2004) , 10.1016/J.BCP.2003.10.035
J. Cléophax, M. Liagre, A. Loupy, A. Petit, Application of Focused Microwaves to the Scale-Up of Solvent-Free Organic Reactions Organic Process Research & Development. ,vol. 4, pp. 498- 504 ,(2000) , 10.1021/OP000031E