Mitochondrial transcription factor A is the major protein in rodent hepatocytes that recognizes DNA lesions induced by N-acetoxy-acetylaminofluorene.
作者： Monika Pietrowska , Izabela Kołodziejczyk , Piotr Widłak
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摘要: Extracts from rodent liver cells contain an abundant protein that recognizes DNA adducts induced by the chemical carcinogen N-acetoxy-acetylaminofluorene (AAAF). This also has a strong affinity for damaged cisplatin (DDP), but not benzo(a)pyrene diolepoxide or UV-radiation, and been termed AAAF/DDP-DDB. Here we purified this rat tissue analyzed it mass spectrometry identified as mitochondrial transcription factor A (TFAM). Experiments with bacterially expressed recombinant TFAM confirmed its high AAAF. Assuming abundance specificity AAAF lesions, may significantly impede recognition repair of other derivatives 2-aminofluorene.
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