Context and Barriers to the Prescription of Nonoccupational Postexposure Prophylaxis Among HIV Medical Care Providers: National Internet-Based Observational Study in China.

摘要: Background: Nonoccupational postexposure prophylaxis (nPEP) is an effective HIV biomedical prevention strategy. The research and use of nPEP are mainly concentrated in the developed world, while little known about knowledge, attitudes, practices among medical care providers developing countries. Objective: We aimed to assess knowledge prescribing practice mainland China. Methods: were recruited China during May June 2019 through online survey regarding nPEP-related clinical prescription experiences. Multivariable logistic regression was performed identify factors associated with providers. Results: A total 777 eligible participants participated this study from 133 cities 31 provinces China. Of participants, 60.2% (468/777) unfamiliar only 53.3% (414/777) ever prescribed nPEP. who worked a specialized infectious disease hospital (vs general hospital, adjusted odds ratio [aOR] 2.49; 95% CI 1.85-3.37), had practiced for 6-10 years 5 or fewer years, aOR 3.28; 2.23-4.80), 11 more 3.75; 2.59-5.45), previously occupational PEP (oPEP, 4.90; 3.29-7.29) significantly positive association However, unfamiliarity (aOR 0.08; 0.05-0.11), believing may promote high-risk behavior 0.53; 0.36-0.77) result drug resistance key populations, self-reported having no written oPEP guideline place 0.35-0.79) negatively behavior. Conclusions: have insufficient inadequate proportion prescribing, which impede scale-up services curb acquisition. implementation tailored training retraining would improve situation.