Latent herpes simplex virus type 1 DNA is not extensively methylated in vivo
作者： G. R. Dressler , D. L. Rock , N. W. Fraser
DOI: 10.1099/0022-1317-68-6-1761
关键词:
摘要: SUMMARY The methylation pattern of herpes simplex virus type 1 (HSV-1) DNA, present in the central nervous system latently infected mice, was examined by digestion DNA with methylation-sensitive restriction endonucleases and Southern blot hybridization. Using enzymes Sinai, XmaI, SalI SacII, data indicate no extensive latent HSV-1 vivo. Thus, viral genome is not a necessary condition for, or consequence maintaining, state
sgmjournals.org参考文章(21)
Walter Doerfler, Klaus-Dieter Langner, Inge Kruczek, Lily Vardimon, Doris Renz, Specific Promoter Methylations Cause Gene Inactivation Springer, New York, NY. pp. 221- 247 ,(1984) , 10.1007/978-1-4613-8519-6_11
Edward K. Wagner, Individual HSV Transcripts Springer, Boston, MA. pp. 45- 104 ,(1985) , 10.1007/978-1-4613-2383-9_2
D L Rock, N W Fraser, Latent herpes simplex virus type 1 DNA contains two copies of the virion DNA joint region. Journal of Virology. ,vol. 55, pp. 849- 852 ,(1985) , 10.1128/JVI.55.3.849-852.1985
D A Galloway, C M Fenoglio, J K McDougall, Limited transcription of the herpes simplex virus genome when latent in human sensory ganglia. Journal of Virology. ,vol. 41, pp. 686- 691 ,(1982) , 10.1128/JVI.41.2.686-691.1982
Richard B. Tenser, Marilyn Dawson, Steven J. Ressel, Marie E. Dunstan, Detection of herpes simplex virus mRNA in latently infected trigeminal ganglion neurons by in situ hybridization Annals of Neurology. ,vol. 11, pp. 285- 291 ,(1982) , 10.1002/ANA.410110309
N. W. Fraser, W. C. Lawrence, Z. Wroblewska, D. H. Gilden, H. Koprowski, Herpes simplex type 1 DNA in human brain tissue. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 78, pp. 6461- 6465 ,(1981) , 10.1073/PNAS.78.10.6461
J. L. McLennan, G. Darby, Herpes simplex virus latency: the cellular location of virus in dorsal root ganglia and the fate of the infected cell following virus activation. Journal of General Virology. ,vol. 51, pp. 233- 243 ,(1980) , 10.1099/0022-1317-51-2-233
Michael McClelland, The effect of sequence specific DNA methylation on restriction endonuclease cleavage Nucleic Acids Research. ,vol. 9, pp. 5859- 5866 ,(1981) , 10.1093/NAR/9.22.5859
Bernard Roizman, The structure and isomerization of herpes simplex virus genomes Cell. ,vol. 16, pp. 481- 494 ,(1979) , 10.1016/0092-8674(79)90023-0
Alvaro Puga, Edouard M. Cantin, Abner Louis Notkins, Homology between murine and human cellular DNA sequences and the terminal repetition of the S component of herpes simplex virus type 1 DNA Cell. ,vol. 31, pp. 81- 87 ,(1982) , 10.1016/0092-8674(82)90407-X