A synthetic route to the alkaloids of the ervatamine group. First total synthesis of (±)-6-oxo-16-episilicine
作者： M.-Lluïsa Bennasar , Bernat Vidal , Joan Bosch
DOI: 10.1039/CC9960002755
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摘要: A general route to silicine-methuenine alkaloids, exemplified by the synthesis of 6-oxo-16-episilicine, involving nucleophilic addition an acetylindole enolate pyridinium salt 2, methoxycarbonylation resulting 1,4-dihydropyridine, controlled catalytic hydrogenation, cyclization on indole 3-position and further functional group manipulations, is reported.
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