Further studies of the human platelet receptor for quinine- and quinine-dependent antibodies.

摘要: Previous studies have shown that the receptor for quinine- and quinidine-dependent antibodies is not expressed on surface of platelets from patients with Bernard-Soulier (B-S) syndrome. We now report data to suggest these lack antibodies. Since B-S are also missing 2 related components GP I complex, lb glycocalicin, our findings may be associated this complex normal platelets. An antibody previously directed against a antigen migrated in position SDS-polyacrylamide gel electrophoresis specifically blocked reaction or Purified however, lacked detectable activity. In contrast, mixture putative structural analog glycoprotein (Mr 210,000) eluted wheat germ affinity columns after chromatography Triton X soluble preparations membranes was contain at least 80% total Our results strongly and/or its high m.w. analog(s).