作者: Robert Scragg
DOI: 10.1017/S1368980011001455
关键词:
摘要: OBJECTIVE There is increasing interest in vitamin D and its possible health effects. The aims of the present overview are to summarise research on common diseases for which there substantial evidence D, identify where may be beneficial discuss public implications these findings. DESIGN Literature search PubMed years 2000 2010 cohort studies with baseline measures 25-hydroxyvitamin (25(OH)D) randomised controlled trials (RCT) supplementation relation fractures, colorectal cancer, CVD all-cause mortality. Risk ratios disease from comparisons between 25(OH)D quantiles were summarised using RevMan software version 5·1 (The Nordic Cochrane Centre, Copenhagen). SETTING Community-based samples recruited into many countries. SUBJECTS Older men women, mostly above 50 age. RESULTS When comparing lowest category highest (or reference), pooled risk ratio (95 % CI) was: 1·34 (1·13, 1·59) fractures nine studies; 1·59 (1·30, 1·95) cancer 1·35 (1·17, 1·56) twelve 1·42 (1·23, 1·63) mortality studies. CONCLUSIONS Cohort show that levels predict increased These associations weak could explained by confounding variables such as obesity physical activity. Because their potential significance, RCT doses ≥50 μg/d required determine whether protects against diseases.