Intracranial self-stimulation effects along the route of the nigro-striatal bundle

摘要: Abstract Recent evidence suggesting a possible dopaminergic nigro-striatal substrate of self-stimulation led us to map this route for both and stimulus-bound motor effects. The results 128 electrode placements show that the nigrostriatal projection supports strong effects from substantia nigra ento-peduncular nucleus. Beyond level, such disappear. Our indicate striatum itself is neutral with regard reinforcement, suggest apparent neutrality cannot be ascribed or other artifacts. These findings require reappraisal hypothesis system, although they are not in conflict idea manipulations may affect through some more general regulatory influence on operant responding.