TP53 mutations, amplification of P63 and expression of cell cycle proteins in squamous cell carcinoma of the oesophagus from a low incidence area in Western Europe
作者： P Tanière , G Martel-Planche , J C Saurin , C Lombard-Bohas , F Berger
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摘要: In Europe, high incidence rates of oesophageal squamous cell carcinoma (SCCE) are observed in western France (Normandy and Brittany) north-eastern Italy. Analysis TP53 mutations tumours from these regions has shown a prevalence at A:T basepairs that may result DNA damage caused by specific mutagens. However, the spectrum low is unknown. We report here mutation analysis 33 SCCE collected Lyon, an area incidence. These were also examined for MDM2 P63 amplification, expression p16INK4a/CDKN2a, cyclin E, p27Kipland Cox2. detected 36% cases (12/33). contrast with incidence, did not show base pairs. was amplified 5/32 tested (15.5%). No amplification found. Expression studies revealed frequent loss p16INK4a/CDKN2a(46%) p27Kipl(25%) expression, overexpression Cyclin E (70%) Cox2 (42%). Overall, results indicate areas present similar pattern molecular alterations but differ type mutations. © 2001 Cancer Research Campaign http://www.bjcancer.com
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sci-hub.se 参考文章(34)
Tudek B, Cieśla Jm, Kowalczyk P, Localization of chloroacetaldehyde-induced DNA damage in human p53 gene by DNA polymerase fingerprint analysis. IARC scientific publications. pp. 279- 293 ,(1999)
Albert J. Tuyns, Cancer risks derived from alcohol. Medical oncology and tumor pharmacotherapy. ,vol. 4, pp. 241- 244 ,(1987) , 10.1007/BF02934520
Cliff Tabin, Arlene Sharpe, Daniel Caput, Christopher Crum, Frank McKeon, Annie Yang, Ronen Schweitzer, Deqin Sun, Mourad Kaghad, Nancy Walker, Roderick T. Bronson, p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development Nature. ,vol. 398, pp. 714- 718 ,(1999) , 10.1038/19539
E. Steliarova-Foucher, M. Laversanne, J. Ferlay, D. Forman, S. Antoni, Freddie Ian Bray, C. Gombe Mbalawa, B. Kohler, M. Piñeros, D. H. Brewster, I. Soerjomataram, R. Swaminathan, Cancer Incidence in Five Continents ,(1997)
M. Bak, R. Montesano, J. A. Welsh, M. C. Hollstein, C. C. Harris, L. Peri, A. M. Mandard, R. A. Metcalf, Genetic analysis of human esophageal tumors from two high incidence geographic areas: frequent p53 base substitutions and absence of ras mutations. Cancer Research. ,vol. 51, pp. 4102- 4106 ,(1991)
MP Audrezet, M Robaszkiewicz, B Mercier, JB Nousbaum, JP Bail, E Hardy, A Volant, P Lozac'h, JF Charles, H Gouerou, C Ferec, TP53 Gene Mutation Profile in Esophageal Squamous Cell Carcinomas Cancer Research. ,vol. 53, pp. 5745- 5749 ,(1993)
Christoph Barnas, Ghyslaine Martel-Planche, Yoichi Furukawa, Monica Hollstein, Ruggero Montesano, Pierre Hainaut, Inactivation of the p53 protein in cell lines derived from human esophageal cancers International Journal of Cancer. ,vol. 71, pp. 79- 87 ,(1997) , 10.1002/(SICI)1097-0215(19970328)71:1<79::AID-IJC14>3.0.CO;2-4
Paola Pisani, D. Maxwell Parkin, Freddie Bray, Jacques Ferlay, Estimates of the worldwide mortality from 25 cancers in 1990. International Journal of Cancer. ,vol. 83, pp. 18- 29 ,(1999) , 10.1002/(SICI)1097-0215(19990924)83:1<18::AID-IJC5>3.0.CO;2-M
Sanjeev Aggarwal, Neelam Taneja, Lin Lin, Mark B. Orringer, Alnawaz Rehemtulla, David G. Beer, Indomethacin-induced apoptosis in esophageal adenocarcinoma cells involves upregulation of Bax and translocation of mitochondrial cytochrome C independent of COX-2 expression. Neoplasia. ,vol. 2, pp. 346- 356 ,(2000) , 10.1038/SJ.NEO.7900097
Awad Shamma, Yuichiro Doki, Toshimasa Tsujinaka, Hitoshi Shiozaki, Masatoshi Inoue, Masahiko Yano, Kensyu Kawanishi, Morito Monden, Loss of p27KIP1 Expression Predicts Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma Oncology. ,vol. 58, pp. 152- 158 ,(2000) , 10.1159/000012092