Genipin cross-linked chitosan hydrogel for the controlled release of tetracycline with controlled release property, lower cytotoxicity, and long-term bioactivity

摘要: To realize the controlled release property, lower cytotoxicity, and long-term bioactivity of tetracycline, chitosan hydrogel had been prepared using genipin as cross-linker tetracycline was in situ encapsulated. The formation process strength were studied by rheological analysis, microtopography observed scanning electron microscope. It found that amount could modulate physical property hydrogel. For vitro antibacterial assays, controllably keep its for a long time. tetracycline-loaded showed good effect even under alkaline environment, which displayed better stability compared with free tetracycline. Moreover, exhibited cytotoxicity than did alone, suggesting this be more useful dosage form separate doses novel aspects study include vivo might other researchers field.