Deformable microparticles for shuttling nanoparticles to the vascular wall.
作者： Omolola Eniola-Adefeso , Catherine A Fromen , Alison L Banka , Michael Holinstat , Margaret B Fish
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摘要: Vascular-targeted drug carriers must localize to the wall (i.e., marginate) and adhere a diseased endothelium achieve clinical utility. The particle size has been reported as critical physical property prescribing margination in vitro vivo blood flows. Different transport process steps yield conflicting requirements-microparticles are optimal for margination, but nanoparticles better intracellular or tissue delivery. Here, we evaluate deformable hydrogel microparticles transporting vascular wall. Depending on microparticle modulus, nanoparticle-loaded poly(ethylene glycol)-based delivered significantly more 50-nm vessel than freely injected alone, resulting >3000% delivery increase. This work demonstrates benefit of optimizing microparticles' efficient enhance nanocarriers'
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