Mechanisms causing plateau potentials in spinal motoneurones.
作者： Aidas Alaburda , Jean-François Perrier , Jørn Hounsgaard
DOI: 10.1007/978-1-4615-0713-0_27
关键词:
摘要: Plateau potentials are generated by a voltage sensitive persistent inward current. In spinal motoneurones this current is predominantly mediated influx of Caei through L-type Cae` channels the Cav1.3 subtype. Depolarisation-induced facilitation Ca. thought to be mechanism for delayed activation (wind-up and warm-up) plateau potential hysteresis in firing frequency I-V relation during triangular depolarisation. Cae’ facilitated metabotropic receptors glutamate, acetylcholine, noradrenaline serotonin down regulated GABAareceptors. The has been shown depend on activated calmodulin.
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