Paternal age and risk of testicular germ cell tumors: a cohort study of 1,000,000 men.

摘要: Testicular germ cell tumors (TGCT) are the most frequent cancer among young men, with increasing incidence worldwide. Advanced paternal age has been linked to adverse health outcomes in offspring, but reports on association of TGCT few and inconsistent. We aimed examine relationship (PAB) at birth risk by histologic type: seminoma non-seminoma. A population-based cohort 1,056,058 males, examined ages 16-19 between years 1980-2011, was Israel National Cancer Registry obtain incident through 2012. applied multivariable Cox regression. During 16.5 million person-years follow-up, 1247 cases (604 seminomas 643 non-seminomas) were detected. Increasing PAB linearly associated lower (HRper year  = 0.983, 95% CI: 0.974-0.993, p = 0.001), after adjustment for birth, education, height, cryptorchidism history origin, also additional maternal (MAB)  = 0.980: 0.965-0.995, p = 0.008). The stronger  = 0.968: 0.946-0.989, p = 0.004) persisted a subset adjusted sibship size  = 0.950: 0.917-0.983, p = 0.003). In fully model, (15-24 vs. ≥30) factor (HR = 1.41: 1.07-1.85, p = 0.014). models PAB, MAB not TGCT. conclusion, our findings suggest that is TGCT, especially seminoma. warrant further investigation into possible impact their offsprings' testes.