The Genetics of Diabetic Nephropathy
作者： Eoin Brennan , Caitríona McEvoy , Denise Sadlier , Catherine Godson , Finian Martin
DOI: 10.3390/GENES4040596
关键词:
摘要: Up to 40% of patients with type 1 and 2 diabetes will develop diabetic nephropathy (DN), resulting in chronic kidney disease potential organ failure. There is evidence for a heritable genetic susceptibility DN, but despite intensive research efforts the causative genes remain elusive. Recently, genome-wide association studies have discovered several novel variants associated DN. The identification such may potentially allow early at risk patients. Here we review current understanding key molecular mechanisms architecture discuss merits employing an integrative approach incorporate datasets from multiple sources (genetics, transcriptomics, epigenetic, proteomic) order fully elucidate elements contributing this serious complication diabetes.
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