Prescription prevalence of psychotropic drugs in children and adolescents: an analysis of international data

摘要: We conducted a review and meta-analysis to establish the international pooled prevalence of psychotropic drugs in children adolescents, comment on recent trends. Medline, Embase, PsycINFO were searched for studies with annual estimates attention deficit hyperactivity disorder (ADHD) medications, antidepressants, antipsychotics, sedative/hypnotics anxiolytics outpatient adolescents. Data extracted regarding representativeness, sampling frame, quality reporting. A total 59 reporting data 23 countries collected. Most Europe (42) at high or moderate risk bias (35). The global random-effect was 15.3‰ (95% confidence interval [CI], 7.6–25.7‰) ADHD 6.4‰ (95%CI 4.3–8.7) 5.5‰ 3.6–7.8) antipsychotics. Heterogeneity extremely (I2 > 99%). Large increases found medications most countries, particularly up until 2010. antidepressants’ trend U-shaped lowest 2007–2009 rise more recently. weak antipsychotics seen 2011, contrasting limited. study provides paediatric drug its Systematic monitoring is lacking very heterogeneous common across studies.