Effect of duration of treatment on treatment outcome and cost of treatment for Wilms' tumor: a report from the National Wilms' Tumor Study Group.
作者： D M Green , N E Breslow , J B Beckwith , J Z Finklestein , P Grundy
DOI: 10.1200/JCO.1998.16.12.3744
关键词:
摘要: PURPOSENational Wilms' Tumor Study (NWTS)-4 was designed to evaluate the efficacy, toxicity, and cost of administration different regimens for treatment tumor (WT).PATIENTS AND METHODSBetween August 6, 1986 September 1, 1994, 905 previously untreated children aged younger than 16 years with stage II favorable histology (FH) WT (low-risk [LR]), stages III IV FH WT, or I clear-cell sarcoma kidney (high-risk[HR]) were randomized after completion 6 months chemotherapy discontinue (short) continue 9 additional (long) that included vincristine either divided-dose (standard [STD]) courses (5 days) single-dose (pulse-intensive [PI]) dactinomycin. HR patients also received (STD) (3 (PI) doxorubicin.RESULTSThe 4-year relapse-free survival (RFS) rates second randomization LR 83.7% 190 p...
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