摘要: Abstract Current approaches to Systems Medicine are mostly research-focused and concentrate on emergent properties the cellular level (e.g., cancer) based descriptions of molecular complexity. Initial steps integrate tissue, organ organism levels exist must extend environmental social systems even if not every aspect humanity can be represented (yet). provides a paradigm shift from parts-oriented reductionism process-oriented holism developing valid causal theory how ‘bio’, ‘psycho’ ‘socio’ actually relate. Delivering this conceptual progress will require similar shifts in organisation healthcare public health.