Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes
作者： Richard Mackenzie , Bradley Elliott
DOI: 10.2147/DMSO.S48260
关键词:
摘要: … insulin signaling pathway in skeletal muscle. Pathways in type 2 diabetes stimulated by insulin … be promoted via two distinct pathways, ie, insulin-dependent mechanisms resulting in …
doaj.org参考文章(83)
Thomas H. Reynolds, Joseph T. Brozinick, M. A. Rogers, Samuel W. Cushman, Mechanism of hypoxia-stimulated glucose transport in rat skeletal muscle: potential role of glycogen American Journal of Physiology-endocrinology and Metabolism. ,vol. 274, ,(1998) , 10.1152/AJPENDO.1998.274.5.E773
Olle Stål, Gizeh Pérez-Tenorio, Linda Åkerberg, Birgit Olsson, Bo Nordenskjöld, Lambert Skoog, Lars Erik Rutqvist, Akt kinases in breast cancer and the results of adjuvant therapy Breast Cancer Research. ,vol. 5, pp. 1- 8 ,(2003) , 10.1186/BCR569
Jih-I Yeh, Eric A. Gulve, Lucia Rameh, Morris J. Birnbaum, The effects of wortmannin on rat skeletal muscle. Dissociation of signaling pathways for insulin- and contraction-activated hexose transport. Journal of Biological Chemistry. ,vol. 270, pp. 2107- 2111 ,(1995) , 10.1074/JBC.270.5.2107
L. J. Goodyear, F. Giorgino, T. W. Balon, G. Condorelli, R. J. Smith, Effects of contractile activity on tyrosine phosphoproteins and PI 3-kinase activity in rat skeletal muscle American Journal of Physiology-endocrinology and Metabolism. ,vol. 268, ,(1995) , 10.1152/AJPENDO.1995.268.5.E987
G. D. Cartee, A. G. Douen, T. Ramlal, A. Klip, J. O. Holloszy, Stimulation of glucose transport in skeletal muscle by hypoxia Journal of Applied Physiology. ,vol. 70, pp. 1593- 1600 ,(1991) , 10.1152/JAPPL.1991.70.4.1593
Eiichiro Nagata, Hongbo R. Luo, Adolfo Saiardi, Byoung-Il Bae, Norihiro Suzuki, Solomon H. Snyder, Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death Journal of Biological Chemistry. ,vol. 280, pp. 1634- 1640 ,(2005) , 10.1074/JBC.M409416200
Usha Padmanabhan, D. Eric Dollins, Peter C. Fridy, John D. York, C. Peter Downes, Characterization of a Selective Inhibitor of Inositol Hexakisphosphate Kinases USE IN DEFINING BIOLOGICAL ROLES AND METABOLIC RELATIONSHIPS OF INOSITOL PYROPHOSPHATES Journal of Biological Chemistry. ,vol. 284, pp. 10571- 10582 ,(2009) , 10.1074/JBC.M900752200
Silvie C. STEIN, Angela WOODS, Neil A. JONES, Matthew D. DAVISON, David CARLING, The regulation of AMP-activated protein kinase by phosphorylation. Biochemical Journal. ,vol. 345, pp. 437- 443 ,(2000) , 10.1042/BJ3450437
Aimee D. Kohn, Scott A. Summers, Morris J. Birnbaum, Richard A. Roth, Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation Journal of Biological Chemistry. ,vol. 271, pp. 31372- 31378 ,(1996) , 10.1074/JBC.271.49.31372
Laura S. Harrington, Greg M. Findlay, Richard F. Lamb, Restraining PI3K: mTOR signalling goes back to the membrane Trends in Biochemical Sciences. ,vol. 30, pp. 35- 42 ,(2005) , 10.1016/J.TIBS.2004.11.003