Effect of 3-butyl-1-phenyl-2-(phenyltelluro)oct-en-1-one on oxidative stress in cerebral cortex of rats.
作者： Jordana Penz , Tanise Gemelli , Carlos Augusto Souza Carvalho , Robson Brum Guerra , Lívia Oliboni
DOI: 10.1016/J.FCT.2009.01.004
关键词:
摘要: The objective of this study was to verify the effect organochalcogen 3-butyl-1-phenyl-2-(phenyltelluro)oct-en-1-one on some parameters oxidative stress in brain 10-day-old rats. Cerebral cortex incubated for 1h presence or absence 1, 10 30 microM and thiobarbituric acid reactive substances (TBARS), carbonyl, sulfhydryl, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), S-transferase (GST), nitric oxide (NO) production release cytosolic enzyme lactate dehydrogenase (LDH) were measured. organotellurium not capable alter TBARS carbonyl assays. In contrast, compound at provoked a reduced protein thiol groups measured by sulfhydryl assay. Furthermore, activity antioxidant CAT (10 microM) GPx (1, organochalcogen. On other hand, SOD GST enhanced respectively compound. NO also increased 30muM Finally, we verified that enhance LDH concentration. Our findings indicate induces vitro cerebral rats being potentially toxic
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