Prognostic evaluation and choice of second-line treatment for patients with advanced non-small-cell lung cancer

作者: Massimo Di Maio , Alessandro Morabito , Gennaro Daniele , Pasqualina Giordano , Maria Carmela Piccirillo

DOI: 10.2217/LMT.12.4

关键词:

摘要: SUMMARY Patients with progressive disease after first-line treatment for advanced non-small-cell lung cancer have a limited life expectancy. In the second-line setting, better understanding of prognostic factors and availability score can contribute to sensible evaluation risks benefits associated treatment. We previously showed that prognosis patients receiving is significantly conditioned by gender, performance status, histology, stage, previous platinum use response A based on these allows classification into three categories. The simple calculate because all variables considered are routinely collected as part baseline clinical patients. For majority patients, in absence known molecular predictive factors, choice among drugs demonstrated efficacy s...

参考文章(24)
Frank V. Fossella, Russell DeVore, Ronald N. Kerr, Jeffrey Crawford, Ronald R. Natale, Frank Dunphy, Leonard Kalman, Vincent Miller, Jin Soo Lee, Melvin Moore, David Gandara, Daniel Karp, Everett Vokes, Mark Kris, Yong Kim, Francis Gamza, Luz Hammershaimb, , Randomized Phase III Trial of Docetaxel Versus Vinorelbine or Ifosfamide in Patients With Advanced Non–Small-Cell Lung Cancer Previously Treated With Platinum-Containing Chemotherapy Regimens Journal of Clinical Oncology. ,vol. 18, pp. 2354- 2362 ,(2000) , 10.1200/JCO.2000.18.12.2354
Filippo de Marinis, Antonio Rossi, Massimo Di Maio, Serena Ricciardi, Cesare Gridelli, Treatment of advanced non-small-cell lung cancer: Italian Association of Thoracic Oncology (AIOT) clinical practice guidelines Lung Cancer. ,vol. 73, pp. 1- 10 ,(2011) , 10.1016/J.LUNGCAN.2011.02.022
Gabriella Farina, Flavia Longo, Olga Martelli, Ida Pavese, Andrea Mancuso, Luca Moscetti, Roberto Labianca, Alessandro Bertolini, Enrico Cortesi, Antonio Farris, Daniele Fagnani, Maria Cristina Locatelli, Giuseppe Valmadre, Antonio Ardizzoia, Maurizio Tomirotti, Eliana Rulli, Marina Chiara Garassino, Alberto Scanni, Rationale for treatment and study design of tailor: a randomized phase III trial of second-line erlotinib versus docetaxel in the treatment of patients affected by advanced non-small-cell lung cancer with the absence of epidermal growth factor receptor mutations. Clinical Lung Cancer. ,vol. 12, pp. 138- 141 ,(2011) , 10.1016/J.CLLC.2011.03.008
Raffaele Costanzo, Maria Carmela Piccirillo, Claudia Sandomenico, Guido Carillio, Agnese Montanino, Gennaro Daniele, Pasqualina Giordano, Jane Bryce, Gianfranco De Feo, Massimo Di Maio, Gaetano Rocco, Nicola Normanno, Francesco Perrone, Alessandro Morabito, Gefitinib in Non Small Cell Lung Cancer BioMed Research International. ,vol. 2011, pp. 815269- 815269 ,(2011) , 10.1155/2011/815269
Luis Paz-Ares, None, Beyond first-line NSCLC therapy: chemotherapy or erlotinib? Lancet Oncology. ,vol. 13, pp. 225- 227 ,(2012) , 10.1016/S1470-2045(12)70001-3
Marie Florescu, Baktiar Hasan, Lesley Seymour, Keyue Ding, Frances A. Shepherd, A Clinical Prognostic Index for Patients Treated with Erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21 Journal of Thoracic Oncology. ,vol. 3, pp. 590- 598 ,(2008) , 10.1097/JTO.0B013E3181729299
Tudor Ciuleanu, Lilia Stelmakh, Saulius Cicenas, Skaidrius Miliauskas, Alexandru Calin Grigorescu, Carina Hillenbach, Hrefna Kristin Johannsdottir, Barbara Klughammer, Emilio Esteban Gonzalez, Efficacy and safety of erlotinib versus chemotherapy in second-line treatment of patients with advanced, non-small-cell lung cancer with poor prognosis (TITAN): a randomised multicentre, open-label, phase 3 study Lancet Oncology. ,vol. 13, pp. 300- 308 ,(2012) , 10.1016/S1470-2045(11)70385-0
Massimo Di Maio, Maciej Krzakowski, Ronan Fougeray, Dariusz M. Kowalski, Cesare Gridelli, Prognostic score for second-line chemotherapy of advanced non-small-cell lung cancer: external validation in a phase III trial comparing vinflunine with docetaxel. Lung Cancer. ,vol. 77, pp. 116- 120 ,(2012) , 10.1016/J.LUNGCAN.2012.01.013
Jean-Yves Douillard, Frances A. Shepherd, Vera Hirsh, Tony Mok, Mark A. Socinski, Radj Gervais, Mei-Lin Liao, Helge Bischoff, Martin Reck, Mark V. Sellers, Claire L. Watkins, Georgina Speake, Alison A. Armour, Edward S. Kim, Molecular Predictors of Outcome With Gefitinib and Docetaxel in Previously Treated Non–Small-Cell Lung Cancer: Data From the Randomized Phase III INTEREST Trial Journal of Clinical Oncology. ,vol. 28, pp. 744- 752 ,(2010) , 10.1200/JCO.2009.24.3030