Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG).

摘要: Neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s (PD) enforce an overwhelming social economic burden on society. They are primarily characterized through the accumulation of modified proteins, which further trigger biological responses inflammation, oxidative stress, excitotoxicity modulation signalling pathways. In a hope for cure, these have been studied extensively over last decade to successfully develop symptom-oriented therapies. However, so far no definite cure has found. Therefore, there is need identify class drug capable reversing neural damage preventing death. This review therefore assesses reliability neuroprotective benefits epigallocatechin-gallate (EGCG) by shedding light their biological, pharmacological, antioxidant metal chelation properties, with emphasis ability invoke range cellular mechanisms in brain. It also discusses possible use nanotechnology enhance EGCG.