Expression of tyrosine hydroxylase in the aging, rodent olfactory system

摘要: Tyrosine hydroxylase (TH) mRNA, immunoreactivity, and activity were examined as a reflection of dopamine expression in juxtaglomerular neurons intrinsic to the olfactory bulbs young (6-month-old), middle aged (18-month-old), (25- 29-month-old) rats mice. TH was maintained at levels observed animals from two mouse strains, C57Bl/6JNia C57Bl/6NNia, one rat strain, an F1 hybrid between F344 Brown Norway strains. The parental strain exhibited reductions about 20% 26- 29-month-old compared 6- 18 month-old rats. However, there significant inter-animal variability. Some had that similar others 50% those animals. Neither general condition nor presence adrenal tumors predicted individuals with reduced expression. Olfactory bulb size, estimated protein content, did not differ mice different ages. In addition, marker protein, found primarily mature receptor neurons, also unchanged indicating maintenance afferent innervation. These data suggest that, contrast other brain systems, phenotype is aging bulb.