CTRP3 attenuates cardiac dysfunction, inflammation, oxidative stress and cell death in diabetic cardiomyopathy in rats.
作者： Zhen-Guo Ma , Yu-Pei Yuan , Si-Chi Xu , Wen-Ying Wei , Chun-Ru Xu
DOI: 10.1007/S00125-017-4232-4
关键词:
摘要: Aims/hypothesis Oxidative stress, inflammation and cell death are closely involved in the development of diabetic cardiomyopathy (DCM). C1q/tumour necrosis factor-related protein-3 (CTRP3) has anti-inflammatory properties but its role DCM remains largely unknown. The aims this study were to determine whether CTRP3 could attenuate clarify underlying mechanisms.
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sci-hub.se 参考文章(45)
Dan Wu, Hong Lei, Jin-Yu Wang, Cheng-Lin Zhang, Han Feng, Feng-Ying Fu, Li Li, Li-Ling Wu, CTRP3 attenuates post-infarct cardiac fibrosis by targeting Smad3 activation and inhibiting myofibroblast differentiation. Journal of Molecular Medicine. ,vol. 93, pp. 1311- 1325 ,(2015) , 10.1007/S00109-015-1309-8
Qi Hou, Jinyan Lin, Wentao Huang, Maoyin Li, Jianhua Feng, Xiangming Mao, CTRP3 Stimulates Proliferation and Anti-Apoptosis of Prostate Cells through PKC Signaling Pathways PLOS ONE. ,vol. 10, ,(2015) , 10.1371/JOURNAL.PONE.0134006
Risa M Wolf, Kimberley E Steele, Leigh A Peterson, Thomas H Magnuson, Michael A Schweitzer, G William Wong, Lower Circulating C1q/TNF-Related Protein-3 (CTRP3) Levels Are Associated with Obesity: A Cross-Sectional Study. PLOS ONE. ,vol. 10, ,(2015) , 10.1371/JOURNAL.PONE.0133955
Johan de Rooij, Fried J. T. Zwartkruis, Mark H. G. Verheijen, Robbert H. Cool, Sebastian M. B. Nijman, Alfred Wittinghofer, Johannes L. Bos, Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP Nature. ,vol. 396, pp. 474- 477 ,(1998) , 10.1038/24884
Xin Li, Li Jiang, Miao Yang, Yu-wen Wu, Su-xin Sun, Jia-zhong Sun, Expression of CTRP3, a Novel Adipokine, in Rats at Different Pathogenic Stages of Type 2 Diabetes Mellitus and the Impacts of GLP-1 Receptor Agonist on It Experimental Diabetes Research. ,vol. 2014, pp. 398518- 398518 ,(2014) , 10.1155/2014/398518
Andreas Schäffler, Christa Buechler, CTRP family: linking immunity to metabolism Trends in Endocrinology & Metabolism. ,vol. 23, pp. 194- 204 ,(2012) , 10.1016/J.TEM.2011.12.003
LU Cai, Yuehui Wang, Guihua Zhou, Teresa Chen, Ye Song, Xiaokun Li, Y James Kang, None, Attenuation by Metallothionein of Early Cardiac Cell Death via Suppression of Mitochondrial Oxidative Stress Results in a Prevention of Diabetic Cardiomyopathy Journal of the American College of Cardiology. ,vol. 48, pp. 1688- 1697 ,(2006) , 10.1016/J.JACC.2006.07.022
Sajad A Hayat, Billal Patel, Rajdeep S Khattar, Rayaz A Malik, Diabetic cardiomyopathy: mechanisms, diagnosis and treatment. Clinical Science. ,vol. 107, pp. 539- 557 ,(2004) , 10.1042/CS20040057
Richard B. Devereux, Mary J. Roman, Mary Paranicas, Michael J. O’Grady, Elisa T. Lee, Thomas K. Welty, Richard R. Fabsitz, David Robbins, Everett R. Rhoades, Barbara V. Howard, Impact of Diabetes on Cardiac Structure and Function The Strong Heart Study Circulation. ,vol. 101, pp. 2271- 2276 ,(2000) , 10.1161/01.CIR.101.19.2271
Heiko Bugger, E. Dale Abel, Molecular mechanisms of diabetic cardiomyopathy. Diabetologia. ,vol. 57, pp. 660- 671 ,(2014) , 10.1007/S00125-014-3171-6