Unequivocal Regeneration of Rat Optic Nerve Axons into Sciatic Nerve Isografts

摘要: It is now established that central axons grow for long distances within a peripheral nerve when the latter implanted into nervous system (CNS) (Aguayo et al. 1979, 1982, 1983, 1984, Richardson 1980, 1981, Benfey and Aguayo 1982). However, poorly penetrate grafts of CNS tissue between cut ends al 1978, Weinberg Spencer Perkins 1980), few regenerate past root/cord junction after dorsal root injury (Kimmel Moyer 1947, 1953, Stensaas 1979), while growing in bridges extend only short beyond both CNS/PNS interfaces (David 1984). Moreover, graft behave like if they are damaged this site, is, readily 1985). This distinctively different behavior two environments suggests growth fails either because factors normally required elongation absent from mature or other possibilities operating, e.g., inhibitors act by blocking receptor sites trophic substances on axonal membrane (Berry