Towards clinical trials of lie detection with fMRI

摘要: Recent reports of successful fMRI-based discrimination between lie and truth in single subjects raised the interest prospective users a public concern about potential scope this technology. The increased scrutiny highlighted lack controlled "real life", i.e. clinical trials technology that conform to common standards medical device development. ethics conducting such given paucity data on detection has also been questioned. To probe issues translating laboratory research into practice, we conducted case study which adapted standard Guilty Knowledge Test (GKT), well-established model producing deception, scenario lying resume. task consisted questions pertinent items subject's resume, three could be independently verified as (KNOWN) not were thus termed UNKNOWN. subject had an incentive all UNKNOWN items, debriefing confirmed he done so. Data was preprocessed, masked with priori regions interest, thresholded, qualitatively evaluated for consistency previously reported prefronto-parietal Lie > Truth pattern. Deceptive responses two out associated predicted fMRI In third pattern absent, instead, limbic (amygdala hippocampus) response observed. Based published pattern, only first categorized Lie. If confirmed, demonstration amygdala hippocampus activation contrast illustrates need integrate system its emotional cognitive correlates existing deception. Our experiment suggests approach naturalistic answered order set stage detection.