Vasopressie-induced sensitization: involvement of neurohypophyseal peptide receptors

摘要: Abstract Rats pretreated with an intracerebroventricular (i.c.v.) injection of 10 pmol vasopressin or vasoprcssin analogs, including deamino- d -vasopressin, [pGlu1,Cyt6]vasopressin, [pGlu-Asn-Cys(Cys)]Pro-Leu-Gly-NH2, des-Gly-NH92-vasopressin, Pro-Leu-Gly-NH2, Pro-Arg-Gly-NH2, became markedly hyper-responsive to the motor effects, 24 h later, a subsequent challenge dose vasopressin, but not vasopressin-related peptides. A V1 receptor antagonist, [d(CH2)15, Tyr(Me)2]vasopressin. V2 Tyr(Et)2,Val4]vasopressin, more selective -Ile2,Ile4]vasopressin, oxytocin Tyr(Me)2, Thr4,Orn8, Tyr-NH92]vasotocin ([d(CH2)15,Tyr(Me)2,Thr4,Tyr-NH92]OVT), blocked and analog-induced sensitization. Furthermore, both antagonists were found sensitize brain injection. This antagonist-induced sensitization was also by antagonist. Next. we wanted determine if this process could involve release endogenous in as reflected amplification mRNA expression. However pretreatment rats i.c.v. associated increase expression bed nucleus stria terminalis, medial amygdala paraventricular hypothalamus when measured 0, 1, 3, 7, 12, after first As many analogs can induce sensitization, suggest that novel type may be involved process.