NOD.H-2h4 mice: an important and underutilized animal model of autoimmune thyroiditis and Sjogren's syndrome.

摘要: NOD.H-2h4 mice express the K haplotype on NOD genetic background. They spontaneously develop thyroiditis and Sjogren's syndrome, but they do not diabetes. Although autoimmune thyroid diseases syndrome are highly prevalent in humans, there has been relatively little emphasis use of animal models these for understanding basic mechanisms involved development therapy chronic organ-specific diseases. The goal this review is to highlight some advantages studying autoimmunity. one few that spontaneously, i.e., without a requirement immunization with antigen adjuvant, both sexes short period time. Thyroiditis early life persist animal. Because animals become clinically ill, mouse provides an excellent model test therapeutic protocols over long availability several mutant background means address impact particular cells molecules Moreover, our knowledge, only which presence or absence single cytokine, IFN-γ, sufficient completely inhibit disease, distinct disease developing when it absent.