Xanthine Oxidase (Xanthine Dehydrogenase)
作者： Rainer Fried , Lygia W. Fried
DOI: 10.1016/B978-0-12-091302-2.50027-X
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摘要: Publisher Summary This chapter focuses on xanthine oxidase (XOD), which is a metal-flavoprotein containing FAD, molybdenum and iron in the ratio of 2:2:8. It oxidizes aldehydes to corresponding acids other substances, including pterins, purines, certain drugs such as allopurinol 6-mercaptopurine. assumed that it takes part alcohol metabolism; plays role incorporation ferritin. High concentrations enzyme have been found intestinal mucosa; this contains copper instead molybdenum. Xanthine has studied model for mitochondrial electron transport subject many reviews. substrate optimum between 0.1 0.2 mM or hypoxanthine. Human blood serum no activity. Mazur Sackler report range 5.49–1.92 units samples obtained from normal human livers, while very low values activity was livers cirrhotic patients cases hemochromatosis.
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