Liver regeneration 4: transcriptional control of liver regeneration.

摘要: Determining what factors are responsible for initiating regeneration following partial hepatectomy or toxic damage, and how the liver maintains differentiated functions while hepatocytes undergoing cellular proliferation central issues in understanding molecular bases of regeneration. Examination transcriptional milieu regenerating provides clues to answers these questions. Growth factor-generated intracellular signals that trigger result activation via posttranslational modifications latent, normally inactive transcription preexist liver. Two activated by this mechanism include posthepatectomy factor/nuclear factor-kappa B) Stat3. Because cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-l (IL-1), IL-6 can induce liver, finding Stat3 PHF/NF-kappa B suggests may play a role some aspects of...