GEP-NET : rare tumour connections. Pathophysiological aspects of gastroenteropancreatic neuroendocrine tumours
作者： Patricia Kuiper
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摘要: Clinical behaviour of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) varies strikingly, both in terms symptoms and outcome. An understanding the basic biology unique to GEP-NETs is necessary for optimum management patients with these complex tumors. Although markers exist, sensitive specific that predict tumor growth are lacking. The general purpose studies described this thesis was investigate epidemiology, diagnosis pathogenesis Netherlands, reveal insights pathological mechanisms contributing development progression Not only worldwide but also incidence increasing. diverse contribute a better role angiogenesis, neuropeptides matrix metallo-proteinases digestive tract pancreas. Additional further research will possible lead new diagnostic therapeutic implications endoglin, bombesin MMPs
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