Adenosine depression of hippocampal neurons in vitro: An intracellular study of dose-dependent actions on synaptic and membrane potentials
作者： G.R. Siggins , P. Schubert
DOI: 10.1016/0304-3940(81)90186-5
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摘要: Abstract In CA1 pyramidal neurons, 5 μM adenosine had no measurable effect on resting membrane potential or resistance, while excitatory and inhibitory postsynaptic potentials generated by orthodromic stimulation of the stratum radiatum were reduced 20–66%. However, 10–20 not only markedly (by 20–80%) synaptic potentials, but also clearly hyperpolarized most neurons. This was accompanied a reduction in input resistance about one-half cells change rest. Monobutyryl cyclic AMP concentrations 50 more usually with resistance.
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