[Cancer genome analysis through next-generation sequencing].

摘要: Cancers are caused by the accumulation of genomic and epigenomic alterations. Particularly, genetic alterations, such as BCR-ABL translocation EGFR mutation, which present only in cancer cells, best therapeutic targets to date. The application next-generation DNA sequencing technologies, including whole-genome, whole-exome whole-transcriptome approaches, has brought substantial advances genomics. These methods will increase efficiency resolution detection somatic genome nucleotide substitutions, small insertions deletions, copy number chromosomal rearrangements. Currently, an international network projects was launched coordinate large-scale studies. greatest impact genomes near future be diagnostics. To provide personalized treatment, development accurate diagnostic tests biomarkers is required surely accelerated technology.